Gliclazide(21187-98-4)
Product List
Gliclazide ndeye sulfonylurea oral antidiabetic drug.Iyo chena crystalline kana crystalline poda, isinganhuhwi uye isinganakidze.
Gliclazide chizvarwa chechipiri chemumuromo sulfonylurea hypoglycemic agent ine chiito chakasimba.Maitiro ayo akafanana neayo toluenosulfonylurea, kureva, inosarudza kuita papancreatic β-masero kusimudzira insulin secretion uye kuwedzera insulin kuburitswa mushure mekudya glucose, iyo isingangogone kuvandudza metabolism yevarwere vane chirwere cheshuga, asi zvakare kuvandudza kana kunonoka kuitika kwe. Diabetic vascular complications.
Gliclazide inonyanya kushandiswa kune yakapfava uye ine mwero mhando II chirwere cheshuga mellitus nekukura kwekutanga uko kudya uye kudzora maekisesaizi chete hazvishande uye pasina katsika ketosis, uye zvakare inovandudza maronda efundus uye metabolic uye vascular dysfunctions muvarwere vane chirwere cheshuga.
Application
Gliclazide inoshandiswa kudzora hyperglycemia mune gliclazide-inopindura chirwere cheshuga mellitus yakagadzikana, yakapfava, isiri-ketosis prone, Type 2 chirwere cheshuga.Inoshandiswa kana chirwere cheshuga chisingakwanisi kudzorwa nekudya kwakaringana uye kurovedza muviri kana kana insulin kurapwa isina kukodzera.
| Test | Zvinotsanangurwa | Migumisiro yekuongorora |
| Chitarisiko | Muchena kana hupfu huchena. | Upfu chena |
| Solubility | Zvinenge zvisinganyunguriki mumvura;yakasununguka soluble mu methylene chloride;zvishoma soluble mu acetone;inonyungudika zvishoma mu ethanol (96 muzana). | Inosangana nezvinodiwa |
| Identifications | Iyo infrared absorption spectrum inowirirana neiyo inowanikwa ne gliclazide CRS. | Inosangana nezvinodiwa |
| Kusachena B (NeHPLC) | ≤2ppm | 0.5ppm |
| Heavy metals | ≤10ppm | <10ppm |
| Zvinoenderana zvinhu (NeHPLC) | Kusachena F ≤0.1% | Asina-kuonekwa |
| Imwe neimwe isina kuchena isina kuchena ≤0.10% | 0.04% | |
| Huwandu hwetsvina kunze kweF ≤0.2% | 0.11% | |
| Kurasikirwa pakuomeswa | ≤0.25% | 0.11% |
| Sulfated ash | ≤0.1% | 0.03% |
| Residual solvents (NeGC) | Ethyl acetate NMT 2500 ppm | 265ppm |
| N,N-Dimethylformamide NMT 880 ppm | Asina-kuonekwa | |
| Assay | 99.0-101.0%, pane yakaomeswa. | 100.0% |
| Mhedziso | Mhinduro dzebvunzo dzinoenderana neEP8. | |
