Ceftiofur Hydrochloride(103980-44-5)
Product Description
Ceftiofur mushonga unorwisa mabhakitiriya werudzi rwecephalosporin (chizvarwa chechitatu), une rezinesi rekushandisa mukurapa kwezvipfuyo.Yakatanga kurondedzerwa muna 1987.
Inoshingirira kune antibiotic resistance enzyme beta-lactamase, uye ine basa rinopesana nemabhakitiriya eGram-positive uye Gram-negative.E. coli marudzi asingamiri ku ceftiofur akashumwa.
Ceftiofur Hydrochloride ndiyo hydrochloride munyu fomu yeceftiofur, semisynthetic, beta-lactamase-yakagadzikana, yakafara-spectrum, yechitatu-chizvarwa cephalosporin ine antibacterial basa.Ceftiofur inosunga uye inactivates penicillin-binding proteins (PBPs) iri pamukati me membrane yebhakitiriya sero wall.PBPs ma enzymes anobatanidzwa mumatanho ekupedzisira ekuunganidza bhakitiriya sero rusvingo uye mukugadzirisa patsva rusvingo rwesero panguva yekukura nekupatsanura.Kusashanda kwePBPs kunokanganisa kuyambuka-kubatanidzwa kwemaketani epeptidoglycan anodiwa kune bhakitiriya sero rusvingo simba uye kusimba.Izvi zvinokonzera kupera simba kwebhakitiriya sero wall uye zvinokonzera cell lysis.
| ZVINHU | SECIFICATIONS | RESULTS | |
| Chitarisiko | Ichena kusvika kuOff-white Crystalline poda | Conform | |
| Identification | Nguva yekuchengetwa kweiyo principal peak mu chromatogram yakawanikwa nebvunzo mhinduro correspoons kune iyo yepamusoro peak mu chromatogram yakawanikwa ine referensi mhinduro. | Conform | |
| Reaction yeChloride | Conform | ||
| Kuonekwa kwemhinduro | Kujeka | Haina kusimba kupfuura No.1 Turbidity Standard | <1 |
| Color | Haina kusviba kupfuura yakajairwa mhinduro Y9 | <8 | |
| Solubility | Soluble muN, N-Dimethylacetamide, zvishoma inonyungudika mu5% ye sodium bicarbonate uye methanol. | Conform | |
| PH | 2.0~3.0 | 2.2 | |
| Mvura Yemukati | 1.5%~4.0% | 1.6% | |
| Specific optical Rotation | -115°~-127° | -117° | |
| Simbi inorema | NMT 0.0020% | Conform | |
| Kusara kwekudzima | NMT 0.20% | 0.15% | |
| Zvinhu zvinoenderana | Kusachena kukuru | NMT 0.20% | 0.09 |
| Zvose zvisina kuchena | NMT 1.50% | 0.38 | |
| Residue solvents | Ethyl Acetate | NMT 0.5000% | 0 |
| THF | NMT 0.0720% | 0.006 | |
| Acetone | NMT 0.5000% | 0.2739% | |
| Benzene | NMT 0.0002% | 0.0001 | |
| Assay | Ceftiofur Hydrochloride | NLT 98.0% | 100.4% |
| Chloride | 6.0%~6.5% | 6.2% | |
| Bacterial Endotoxin | Pasi pe0.20EU/mg | Conform | |
| Kusabereka | Inopindirana nemuedzo | Conform | |
| Chikamu saizi | D (0,1) | <1 | 1.8 |
| D (0,5) | <4 | 1.4 | |
| D (0,9) | <7 | 3.7 | |
| D (1,0) | <10 | 4.2 | |
| MHEDZISO | ZVAKAITIKA ZVINOENDERANA NEZVINOTAURWA | ||
